Inclisiran is the first siRNA therapy for lipid lowering — a twice-yearly injection that silences PCSK9 synthesis in hepatocytes, sustained reduction of LDL by up to 51% (ORION-1 and ORION-10 trials).
Research summaries are AI-generated from open-access peer-reviewed literature (PubMed Central, Cochrane, AHA/ACC). Content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.